Endocrine Abstracts

Epidemiological studies indicate that low circulating concentrations of IGF1 are associated with increased adult risk for the development of type 2 diabetes (T2D) and the metabolic syndrome (MS). Although comparable epidemiological data relating to GH concentrations are lacking, GH deficiency (GHD) is associated with many of the features of the MS and increased T2D risk. These data indicate that reduced activity of the GH/IGF1 axis is a risk factor for MS yet IGF1 and GH have ...

Background: Individuals born Small for Gestational age (SGA) are at high risk of development of type 2 diabetes. Growth hormone (GH) therapy can also adversely affect glucose metabolism.Aim: To explore the factors associated with changes in insulin sensitivity (IS) and insulin secretion during one year of GH treatment in children born SGA.Methods: In the NESGAS clinical trial, we studied 82 (55♂) pre-pubertal children (age 3....